Themed Free Post II Proteasome - Post 4
Well here is an extract from a bibliographic essay that we wrote last year with a group of colleagues on the proteasome.
The proteasome is a molecular protein breakdown
machine that is regulated from birth to breakdown. From the beginning, its
subunits are synthesized in inactive forms or they are readily coupled with
neighboring subunits or chaperones that act as their inhibitors, in such a way
that they are activated after the entire complex has been properly assembled, a
process that is also assisted by chaperones that support independent training
of the CP, the base and the lid of the RP. A mature proteasome (fully assembled
and functional) is located where it is most needed, moving from the nucleus to
the cytoplasm and vice versa. In its basal state it is inactive until it
recognizes a substrate destined for degradation by the union of polyubiquitin
chains, which triggers that all its structures that are interacting closely
with each other undergo a series of conformational changes that lead the
complex to a suitable active state. for the degradation of substrates, which
gives the proteasome this characteristic of being very promiscuous and
selective at the same time in terms of the variety of substrates that it can
degrade.
Checked.
ReplyDelete